Control of mechanically active biological tissues
One of the first steps for developing multicellular systems in vitro with the desired shape and structure is to recapitulate basic morphological changes. We are modulating cell forces and adhesion in monolayer cell sheets that resemble epithelial tissues, using optogenetic tools to control the onset of dynamic behaviors such as cell sorting, migration, or extrusion. We aim to understand how to drive the formation of a diverse array of structures.
What is the role of mechanical communication in cell fate?
Our understanding of cell communication during development has focused almost exclusively on the role of biochemical signals. But mechanical signals are also important! We are interested in how mechanical signals from the environment, particularly the extracellular matrix (ECM), control cell fate and tissue patterning during development.
We are developing ways to control cell mechanics and substrate properties to better understand how mechanical cues can be used to build functional systems such as tissues and organs.